Across the Midwest on Feb. 7, Santorum swept three GOP contests in the primaries -- in Missouri, Minnesota and Colorado.
Santorum's victories last week marked his best performance thus far in the contest for the Republican presidential nomination -- and Romney's worst.
In Oregon County, 116 Democrats were at the polls, with 90 casting ballots for President Barack Obama as he seeks a second term in office.
Also on the Democratic ticket, 6 voted for Randall Terry, 5 for Darcy G. Richardson, 3 for Ron Wolfe and 12 were uncommitted.
Of Oregon County Republicans, 258 cast ballots for Santorum, with 92 for Mitt Romney and 83 for Ron Paul.
Also on the Republican ticket, Rick Perry got 9 votes, Herman Cain 4, John Huntsman 2 and 1 each for Gary Johnson, Michael J. Meehan and Michele Bachmann. Another 25 were uncommitted.
Of 7,454 registered voters in Oregon County, 593 cast ballots, for a turnout of nearly 8 percent.
Santorum also swept Howell, Ozark, Shannon, Texas and Douglas counties, taking at least twice as many votes as Romney or Paul in each county.
Obama had his best showing locally in Texas County, where he landed 196 votes to Paul's 237 and Romney's 266. Santorum garnered 817 votes in Texas County.
After his victory, Santorum told reporters he's finally being heard and supported by conservatives who want a clear contrast to President Barack Obama.
The next focus for the candidates will be Ohio and its vote on Super Tuesday, March 6.
Caucuses will be held locally on March 17.